Dual therapy (Hydroxychloroquine and Azithromycin) at the dosages prescribed at the IHUM does indeed reduce the viral load. Serious error by the health authorities ?

France-Soir, Pixabay Dual therapy (Hydroxychloroquine and Azithromycin) at the dosages prescribed at the IHUM reduces the viral load well. Serious error by health authorities ?

The role of hydroxychloroquine (HCQ) in reducing the viral load of patients with COVID-19 has been the subject of much controversy. It is in this context that Professors Brouqui and Raoult published a new study on July 27, 2024 in the journal Acta Scientific Microbiology.  The medical researchers at the Mediterranean University Hospital Institute (IHUM (1)) have thus put an end to the controversy by demonstrating the efficacy and superiority of dual therapy based on hydroxychloroquine and azithromycin at the dosages prescribed by the IHUM on covid-19 disease in reducing the viral load.

An observational study, patient selection criteria explicitly identified in order to have objectivity and independence

It is therefore with a retrospective observational study of data collected during care that the authors compared the viral clearance determined by qPCR in patients treated with hydroxychloroquine (HCQ) and those who were not. The data were analyzed according to the most important explanatory factors (age, initial viral load and time between the onset of symptoms and treatment). These are 1,276 patients who were selected from the hospital database between March 3, 2020 and March 13, 2021, excluding possible biases on certain conditions, as explained in the diagram below:

The results are clear in favor of dual therapy
In total, 776 patients were treated with HCQ and 500 were not. In the crude analysis, the time from treatment initiation to viral clearance was significantly shorter in the HCQ group than in the untreated group. When adjusted for age, baseline viral load, and time from symptom onset to treatment initiation, the adjusted hazard ratio for viral clearance for the HCQ group remained statistically significant (95% CI hazard ratio 1.18 [1.01-1.38], p = 0.037).

The superiority of dual therapy also confirmed by a new meta-analysis
In order to validate and calibrate their results, the authors carried out a meta-analysis of 9 similar studies involving 1,461 patients treated with HCQ and 958 controls. Viral clearance of SARS-CoV-2 in the HCQ group was significantly shortened after 7 days (54% reduction) and 14 days (147% reduction).

The superiority of dual therapy had already been confirmed on the 30,423 patients treated at the IHU, but criticized.
The IHUM researchers had published a study on the 30,423 patients treated at the IHUM. They concluded that the treatment was superior to the treatment (Hydroxychloroquine and Azithromycin) with a 55% reduction in the risk of mortality. This study was not without criticism, particularly regarding the approval of the research protocol, from opponents of the IHUM researchers, often featured in the media, making insulting and obscene remarks that France-Soir highlighted in the investigation into the harassment sphere (article 1, article 2, article 3). These people were looking for lice when there were patients who had been duly treated at the IHUM.  The world of research is truly ruthless and a ” combat sport “. 

The criticisms were mainly made by Professor Molimard of the University of Bordeaux, who has promoted without limits a fraudulent study (Pradelle, Lega of the University of Lyon). The Pradelle Lega study which falsely estimated “that there could be 17,000 deaths of patients having been treated with hydroxychloroquine”has just been retracted by the publisher after an eight-month audit. It has also been the subject of numerous criticisms of the publisher and a publication exposing its numerous errors, mistakes and biases. This fraudulent study has been taken up in almost all mainstream media in France and abroad in order to further undermine the work of IHUM researchers in order to justify the choices of the vaccination health policy. It also aimed to discredit these world-renowned researchers by undermining their scientific integrity.

An independent analysis of the IHUM patient data, validated by a bailiff, was carried out by Valère Lounnas et al. This study not only corroborated the IHUM results by concluding that “the unquestionable superiority of dual therapy marking a 58% reduction in intensive care and deaths, but went further by showing the aggravating effect of the covid vaccination factor.

The scientific community should take note – end of the controversy ?
This new study published by Philippe Brouqui and Didier Raoult should therefore put an end to the scientific controversy over the effectiveness of dual therapy in reducing the viral load of SARS-Cov2. Combined with other observational studies, we can thus conclude that early treatments are significantly effective in treating Covid early. The scientific community will have to take note of these results, which therefore put an end to the debates around the pseudo-scientific consensus that early treatments do not work. This pseudo-consensus has been used in many documents to justify the authorities' medical choices.

Normally, the scientific community would take note of this study, however, as opponents of the IHUM researchers received the publisher's retraction of the fraudulent Pradelle-Lega study very badly, we can expect the controversy to continue.  Legal proceedings against the authors of the fraudulent study and their promoters have already been announced and associated investigations will probably be necessary in order to identify roles and responsibilities.  The universities of Lyon and Bordeaux, the Ministry of Research contacted were not available to respond.

Victory of early treatments, defeats for patients 
The health authorities will have to draw the consequences on the numerous losses of opportunity of patientswho have not been treated, as well as on the approval of vaccine therapies as the sole treatment against Covid. As a reminder, these therapies have not proven that they reduce the transmission and contamination of the virus by taking risks of significant adverse effects with experimental products.  A fundamental question remains, the effectiveness of dual therapy known since April 2020 by big pharma and the APHP, why was it ignored ?
Such a medical error has serious consequences and should be the subject of an investigation by the health affairs committee in order to determine the ins and outs.

(1)The IHUM is the infectious disease division of the Assistance Publique Hôpitaux de Marseille (APHM) which works jointly with the University of Aix-Marseille on research into infectious diseases.

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