Scientists at the University of Pittsburgh in the United States have solved the mystery of HIV resistance to treatment. Replicons of infected cells infect new cell structures, provoking chronic inflammation.
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The specialists set themselves the goal of uncovering the mystery of why in some cases the therapy used does not improve the well-being of HIV patients by removing viruses from the blood. Compliance with the mandatory course of treatment shows the resistance of the disease. Scientists have found that the cause is clones of HIV-infected cells that produce viruses. Replicons grow to significant sizes and simulate therapy failure. At the same time, modern HIV drugs stably block the infection of new cellular structures, while they cannot affect the production of the virus from cells that are already infected. We are talking about the possible provocation of a chronic inflammatory process.
After stopping therapy, the virus recovers faster. The scientists concluded that replicons of infected cellular structures should be considered the main barrier to the creation of an effective drug against HIV.