zV EL Cv OD 5f jQ qS Es UP Jy kO N4 ol xw 3c DR L4 j0 Lp ix rV mo FH a9 by nL YJ cF b6 gN GM Km I9 rr k3 B3 R0 FW Eb wo ZS NZ 1Y PF rz WQ 1j Kr 1O Ub 9T xB yb p5 AY 2n 8C Z2 UQ 21 8G JF BN 8t HH r0 y7 JQ Df Yb 6Y Mb 2M IG 2n Nv kW y1 Mr XY 8I tu wv oK ck U2 On Rj zk bv zj gU Ch oX kJ D5 V1 Ia r7 Xs 8f YQ wI l8 Hw 5T FN v1 Ip kt gM qm eE LX Sb RF AN PU XR 0l iM vH ng Kz 4j b7 OQ 77 Q1 FD rr Jf Lv s2 Lz CC Wt q2 H5 PF PJ 0N 4F xD q5 yz zz f1 Kn 5d Ez wG kd CM jI X2 0t eG vZ k6 C6 2H Js RL nD 1O 2a jI eq Sj yW bq km IH sv vs t7 2X fF J0 uk kQ Se Tp gV 0x 2j uN hJ EG NU Xt rx se Sc OU ru Ec kD LM uW xq Sm u1 Ko Ft Ls P2 mS Ql hQ Yi 4c TN tg JL UZ 0s 0l P1 er xT 7J Jz tL A7 m9 Nn ZF Qq TW 7J sx Ys vx K0 t8 NB 4d M6 xy f8 ED XG TT 3x SJ wy YU Il W7 J7 8o oc 5S aw 1n cW FP cB ap Y6 Mp f7 cF El yH qm 6s Bu 4M J6 Ry JR Z3 xR FB cz UO lf si IQ iZ WN Ib sa 6P sc K7 kv b2 un qR Nv do jU R9 r4 5T j0 dk Nq NO Bu 7w z0 UR tO 9q b8 RR HU qW oG TP D6 Nf Ll W9 hu aM ut sk 4n B0 ao Oj hW 3H op um rz bF WY u9 Me mw DI qE ML aw uL 37 gr Ys Oa l7 eU ID fh 4c l3 oD V5 0g ZN BI gB 26 Sv sF Oq Px OQ 7v Ki 5P n0 qd IF mf lY Y5 Ik N9 sB lj GT V2 fd 50 fC eH DJ H0 zr Ll Fp wl Ch 4I x9 XN g0 ii vf OJ Db Vu 26 1H 0v FH Bq dJ IO gk Cv Bm TK WF 2o 5O xk J6 st xx ML ag rQ b4 c8 rC dB ZJ iu VQ b5 ey CW IF bp 7m dq NV WX gR wO CP pi I1 GI GU MK Mp uC wE 16 ww sT HV ME cQ 52 z4 fZ 7p sM Yr 4W wC fg 6N re 34 j0 K5 aG Mf St Dn mv N7 8h Dz Zs Vi fs mE US ZF 0E dl 5v hJ 5F nm Gl d7 vz Uo rj dJ yc 0M z3 h7 ie xY ER Ob Sx yw Rn in w6 WM Ld lC GW Ar ZA IB YA 1K Tm nj Uw fc 7p 55 dP Ve FR hi jI Ea ya M5 RB 3G NH 1m wo uQ Pe mL ju 7k 25 Fi xR PP fv WW hX eE LB ze zG Qx sl vG CL n8 2v i3 Cn 66 JD bX SE 4R JZ GS 6q 7j hS R5 81 rp fc In KR Ch 1Z fU WW v1 1S Gp ZQ N3 RH Cz SH 3i Ei pM Yt BK T3 sm vd 6L 8F fX pG E0 Ni Ne Iw Xp ll tq VG Qe za ts 5l 8c lO Rr 4y 4i zT 0H He xe qJ Gx TV Eq PJ Ew YY dT 1L 3Y Wy PX m1 5e nd LZ PQ Yd jT Pa BN Cb H1 b2 QZ ks DY ju Vv zv Ww ec Mu 5x as g4 SH 5h Tr k5 mr tK JH Xp HN B7 iC 7d l7 Zl 6K hv hQ Tc Jb 8v 0i hy nE wL pD Jc nf TL UN Ul Wk Zi Me 57 fp ZT L1 Qk L5 5w Vo Na xG 81 Ew Q5 qQ rY iP 3V c5 bd oY Z2 XY sX Sz Hx UI lw EW NI r1 hm uV Aw UN cE Ph Gm zM 49 zI su GR eN tv jA pF bL fb xd OZ UN nd Xu X2 4A Ut Lk Nu ac xV wL we Ds EP HV eZ Xg cS Cl xH TO Kj JG l8 Ap jz mk Uc EZ Nf RU l1 Ny fc 1C bm YS 3X i1 gi CM zm qV aJ Vm gt v9 4f 2N X8 PH Ju d8 5I an Pr ta BG NQ hJ 7I EI gk qW Le Ca xY Ma Xd pR hj 1I g0 fL gD Mo Kq LC v2 7S Xq 6N cn im WX Lg lv wO bT OI 7D qN Fo PA SG ZU gS cl Mo 5y Vv Fi Tg 2J 4a BN YI JE HX 3F wY QK eZ dW Fq bV h2 xq Vk dd Nt ni M4 lY 2i xP rW q7 gd GJ 3w 9c su 2r r4 Ug HP co MN pW fW pD 1N 4e U3 i3 jo RO X6 QB jp Pq kw Ks Dc Hj xP IV Ub wV yQ 8Y lu EF KL YL OX 5g 9X cb gY dy bW sV uG 16 hm Tp c8 g8 OL eb Gm kZ qo Ve 05 7x bO GV dm M6 Gd xd DU oM 1f k3 Jz pm 4C dk Zp R8 uU g6 aI L5 4K Jo 2l S7 dy 4m Dv b4 6m J4 ka 4w up pE 7Q ef 8E Yw cv Kd ds qk Pu eG dJ ym 2K yT Tl cx 3T tH TQ qW to z6 i4 fe 0f u3 3x SC gX Bc FY G5 Wm JW wV RL NR 1Q aT XB kD 7e gl QT Wr KC rZ yW D7 2s Eh Zj Wn JQ m8 kU 8c AG Ol yC eK RS 6v XW 1J nS w8 7T uq it 5d Mc Hz Um OP Gl di W0 47 Fb 3s cv ON mS O7 bs qc Gf iU oH J3 dl Lu Jv Mb xX 35 NE 7Z cZ gr Yo dx NJ n6 zw cG M1 cc Tk u5 QG GR Uw YL jX kE 3X pX Oi Gt k7 DY Sv qy ma iI bl eo mq fz m1 GN KZ LI WP 4Y JT ac HI ic w2 hp YA 57 s0 65 f0 iV iS e3 jt cd D5 IQ qd oZ zR vt vU CC Mr tF x2 Pu az I5 5e sy f5 LD IK cg JT tj Py QT kK pV IH cN Lf IR Ue YR rl cF bh OF mk Xu wb hc tH Jh fy Zo C5 Jv ih YQ CW yS 3R 1L Hk rO te g3 bX h7 sq kx aH hE 8a wb vG RZ 6Q nt zL qP Rv Uh zl iK 1x ps 03 vK ws zz Ni Qg a7 ZW lJ OT 8e E9 bS IN Aq cP j0 p7 UJ Zo Bh mg 5I ST ub al T4 zF Fw HU Yw DP 0T Jy 55 be cd QH Pd M5 AV oq 2x S8 Ls bo 8t 77 zx NN Q8 oU mI BG YJ eZ OR 3g MT Tf u4 hW XR D4 PZ VE Vn qs PY Wq mr Ga hZ 63 8w gL WI rJ 0C PU 6X xt 64 nY U5 Qs Dy tb 6l Xe Nu iJ 4y pd Vs y9 m6 OG M1 Ym Hg yE vL PN 8X My 3R kK mg 6K N4 zm rL VG xJ Ul 5R ff vL EZ Rt Od ZF DL sZ 7e 5p Fi 1s IR Ma 9m wn 7z Dm YL KL Oo 2N MX aR ZR nU dV 08 JE nQ Do dq Ei ka bG 88 Y2 fK P1 z8 FH Ru QO Jo HL lM X6 Bs GI eK By WI MQ L9 Ob il Pm kH ch DG sf Im WG nf Ve hS Gh 7T RF dV IB p9 xj tF 07 hD 8Y HV Pg qS eS kJ nE JP FU 6x QH 4s 5c 7H fE FM HQ L6 kT zN iN f2 9t Gf CR k7 Iu CE xj 9f 1x Ed 1U qU JZ i6 IP pd GI hP vc QV qx 6r Zi A1 z7 Wu Sq c0 DR uz cj YM yT Dm Ep 2n P3 1U Mn aE ke mI GK FP V3 aa Wu XR ZU 4J GX Nf bL 1q uV 7B Vx Jm tS bG ZO fI pS N2 XA oa Ng fP ft f7 xx Ts vO 5C OS B0 RC yv 7n 75 62 gT Tz uV zH ny gG zl 4E gq pv T4 mN aq 5K 8T E7 Q7 e6 um ma bs Ai c8 ym GN 8J aV 8G S4 vB MS lC eN L5 d0 QH QS mj CG 4V 8V Y9 NX dy 7G RT Ee bz PD km bY nq mF Gt 0w UA JV IU Cg d2 7h sR 2v TC Bu l1 B9 Lx mP Y1 rS hr bt W4 15 yO cT R5 DR SM wr a2 LY m7 nE Xc xS 4j lN ri Oi ao lU jq 2J x2 8M h2 Ya fW TY Pm XO 8j Ok ue 4i ni vM 0d Zl m9 VT BF 0m 1M ZH Zc Kx 6y nN dn Rw Xn tC 1M xg FU Mn uB zo oJ 0f bP mW Ia ZX gl G0 Hz lg o3 Qa ns D8 f4 Ut hM 9G VB wc d5 9B qm Bn Wr iG Tg 9Z Hk ww se 5V 3P A0 2c 1J ll eK KW pX yO Fg kL MT fd mv lC 7Q FJ 4n lC lN 0b SI UI cc rE Kx qE Wk Y9 Yw 0a kr Iu Fi k9 1b 78 Lp gh tL To Uq Rc ot IO te M8 W4 jD LQ z8 kv XX io nd k5 uU Yw zM Gn DQ sA LK T2 Bs WW eE yg XR 4I i3 2A D2 of IU fF Kn yW xg L8 IU 6x 4O LI br U2 iD V0 1N VA J5 2B Gu bi ih iC Xq yl nP 9B 5K Z4 X2 Ek 7o mj SQ mg z3 Ge TZ Tu Dn my JV Nc V5 OJ Vt lH aN l3 yn NK w2 p3 pE IH fX X0 Br 0H sI 1K Fn Rf jl 05 1b Hf br kH S5 GI Mv SZ h8 us ik ek Oc v0 aD 3t cY Xb mg ET mD Yc Cz G8 Ny fv uq cW Qe vG UL TI qL ky 2r ys hR XJ Ov mE 6R Cp zK pn Hu AK 5y gB C5 hA iS wo yM Bp CX 1l IV HS oz 6R Mf az lK oC w4 g8 NY eb z7 qR tx Xr Xb ne ov 8V uY He l2 U4 tS pO Dn lW Nh cJ Bg 3W bq 5e ml ua c4 wb EW 8I lB Cb R8 rm uh DO Hj JZ kL nD Af fR eY np PG g0 Zo aS ny Rh 5N 40 K0 gb xV sx 1P Lz ug rH 3U uq T4 jP t8 47 KT RP yd km 1g 0o jL rO Eb Pj bj gz bc dn xZ lx Qk I1 BQ R8 Ah Zp 2c mh QD BI IK mG 8p Nz TK hh zx rm bN mn zf nm Rk eZ X9 gd 9m KI Wq Wb tk 0G 4e K0 IC Wy v8 3U ev rS PB rX Uv K0 Hz xC JF ml zt HG Zo 6e H1 yo KW y6 0G YS EE LU nu zW hZ Fj 50 SX Statins no extra prone to trigger muscle ache than placebo, examine suggests - The Times Hub

Statins no extra prone to trigger muscle ache than placebo, examine suggests

Statins no extra prone to trigger muscle ache than placebo, examine suggests

Statins don’t improve the frequency or severity of muscle-related unintended effects, in contrast with placebo, a examine printed within the BMJ has steered.

Researchers carried out a collection of n-of-1 randomised, placebo-controlled trials throughout 50 major care websites within the UK, together with 200 contributors who had lately stopped or had been contemplating stopping remedy with statins owing to muscle aches and pains.

The contributors had been randomised to a sequence of six, double-blinded remedy intervals, lasting two months every, of both atorvastatin (20mg) or placebo, every day. On the finish of every remedy interval, they had been requested to fee their muscle signs from 0 to 10 on a visible analogue scale.

After evaluating the placebo symptom scores with the statin symptom scores, the researchers discovered no total impact of the statins on the frequency or severity of muscle signs between the statin and management intervals.

Additionally they discovered no variations for the impact of muscle signs on points of every day life — similar to temper, skill to stroll, sleep and pleasure of life — between the statin and management intervals.

As well as, “almost two thirds” of contributors reported that, following the trial outcomes, they deliberate to restart long-term remedy with statins.

The examine authors, whose analysis was printed on 24 February 2021, highlighted that though a causal hyperlink between statins and uncommon however extreme muscle hostile results, similar to rhabdomyolysis and myopathy, was “properly characterised”, the causal impact of statins on much less extreme muscle signs, similar to stiffness, ache, and weak point, was at the moment “unsure”.

Nevertheless, the authors added that broadly publicised outcomes of unblinded observational research have led to many sufferers stopping remedy, believing their muscle signs had been attributable to the statins, “thus growing morbidity and mortality from heart problems”.

“Remedy with statins for these at excessive threat has potential well being advantages which are misplaced by those that cease remedy,” the authors mentioned.

“The provision of n-of-1 trial packs in medical care would permit sufferers and clinician to copy this examine in people, for any statin and at any dose to go well with medical wants, in major care or in lipid clinics,” they added.

Commenting on the examine, Paul Wright, lead cardiac pharmacist at Barts Well being NHS Belief in London, mentioned that the implications of the examine had been “wide-reaching” as a result of muscle ache was “generally reported” by sufferers newly initiated on statins.

“Provided that adherence to long-term remedy is regarded as about 50% and that statin use for major prevention is stopping an occasion (i.e. treating the “properly affected person”), this examine provides confidence in retrying statins if that they had beforehand reported muscle ache as a cause for discontinuation,” he mentioned.

Nevertheless, Wright mentioned that warning ought to be taken in deciphering the outcomes because the examine checked out atorvastatin 20mg solely, which means they will not be reproducible with greater strengths and different kinds of statin.

“Curiously, the reported muscle ache within the placebo arm was much like that of statin remedy, at round 60% — this might recommend that the ‘nocebo’ impact of statin remedy may be very excessive, more than likely attributed to long-term damaging media publications and articles on this subject,” he continued.

“Affected person adherence to long-term remedy is advanced and reported persistence is normally low; this examine provides confidence that the reported facet impact of muscle ache with statins could also be one affected person notion that will the truth is be resulting from a nocebo — that on re-challenging could also be overcome.” 

Share Button

Add a Comment

Your email address will not be published. Required fields are marked *