Scientists have figured out how women can reduce the risk of developing dementia
Scientists from the University of East Anglia have shown that hormone replacement therapy can help prevent Alzheimer's dementia in at-risk women. The study was published in Alzheimer's Research and Therapy.
The authors studied data from 1178 women from 10 countries participating in the European Initiative to Prevent Dementia in Alzheimer's Disease. They found that hormone therapy use was associated with better memory and larger brain volumes (as measured by MRI) among carriers of the APOE4 gene, which increases the risk of developing Alzheimer's disease. The best effect was observed when replacement therapy was started at an early stage of menopause, during perimenopause.
The effects of hormone therapy, if confirmed in clinical trials, can be equated to rejuvenation of the brain for several years.< /p>
According to the authors, about 25% of women in the UK are carriers of the APOE4 gene, and almost two-thirds of patients with Alzheimer's — women. This may be due to the fact that women live longer, and they are also more affected by the genetic risk factor APOE4.
Prepared by: Sergey Daga