It’s about the heat shock protein
New chemicals that can protect against progressive neurodegenerative diseases such as Alzheimer’s disease have been synthesized by specialists from the Ural Federal University. Scientists from the St. Petersburg Institute of Cytology, Russian Academy of Sciences, test them on living organisms.
It is known that in Alzheimer’s disease, one of the most common forms of dementia, the death of brain cells leads to loss of memory and thinking. Scientists have found that one of the main causes of damage to nerve cells is a violation of protein metabolism, which is accompanied by the formation and deposition of amyloid proteins in the intercellular regions of the brain. Insidious substances not only interfere with the transfer of information from cell to cell, but are also capable of killing neurons themselves.
As the “MK” was informed at the Institute of Cytology, specialists knew that the so-called heat shock proteins can fight amyloids. However, it has now become obvious that such proteins can be formed not only under the influence of heat, but also under the influence of certain chemicals. It is these substances, from the group of pyrrolyl- and indolylazines, that were synthesized by the Ural scientists. Then, at the request of colleagues from St. Petersburg, they transferred this substance for study in cell culture.
According to Irina Guzhova, head of the laboratory at the Institute of Cytology of the Russian Academy of Sciences, in an experiment with neurons in mice, it was shown that under the influence of heat shock protein, amyloid formations arose more slowly, and cells lived longer. The institute has already begun testing a new chemical activator of heat shock cells in living organisms. For this, transgenic mice with mutations causing Alzheimer’s disease were selected.
Transgenic mice will be thrown to fight Alzheimer’s disease